FIG. 1.

Hydrocephalus in Cdo^−/− mice. (A) Ten-week-old littermates of the indicated genotype. The arrow indicates the dome-shaped head of the Cdo^−/− mouse. (B) Brains from 8-week old wild-type and Cdo^−/− littermates. The Cdo^−/− brain and olfactory bulbs (arrowhead) exhibit dramatic swelling and hemorrhage, compared to the those of the wild-type littermate. (C and D) Coronal sections of brains from 3-week-old littermates. Brains were stained with nuclear fast red. Enlarged lateral ventricles and disruption of the septum (marked with an asterisk in the Cdo^+/− section) are observed in the Cdo^−/− brain. Size bar, 1 mm.