TABLE 1.
Quantification of cell proliferation and apoptosis in lateral cortices of Cdo+/− and Cdo−/− micea
| Embryonic age | Assay | Genotype
|
||
|---|---|---|---|---|
| Cdo+/− | Cdo−/− | Cdo−/− | ||
| E13.5 | BrdU incorporation | 591 ± 50 | 606 ± 57 | 583 ± 44 |
| Phospho-histone H3 | 40 ± 8.7 | 40 ± 4.6 | 41 ± 5.8 | |
| TUNEL | 3.3 ± 0.6 | 2.7 ± 0.6 | 3.0 ± 0.6 | |
| E15.5 | Phospho-histone H3 | 21.3 ± 5.6 | 21 ± 6.1 | |
| TUNEL | 2.8 ± 1.2 | 2.7 ± 1.0 | ||
| E18.5 | Phospho-histone H3 | 12.4 ± 2.9 | 12.0 ± 6.6 | |
| TUNEL | 16.3 ± 1.3 | 15.8 ± 2.2 | ||
a
Multiple sections from the embryos shown in Fig. 3 are quantified in this table. Analyses of sections from multiple animals produced similar results.