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(A) Structures of chimeric envelopes used for examining the roles of the V1/V2 domains on neutralization sensitivity of V3 epitopes. Chimeric envelopes were constructed in the SF162 backbone (gray bars) by exchanging the V1/V2 and/or V3 domains with the corresponding domains of JR-FL Env (white bars). (B) Comparison of V3 loop sequences of JR-FL and SF162 Env proteins.
