TABLE 2.
Helicase-dependent and -independent functions for Sgs1
| Suppressed function(s) | Sgs1 requirement?a | Reference(s) | Sgs1 helicase requirement?b | Reference(s) | Process |
|---|---|---|---|---|---|
| Crossovers | Yes | 26; this study (Fig. 2) | No (partial?) | This study (Fig. 2) | DSB repair |
| Long conversion tracts | Yes | This study (Fig. 3) | No | This study (Fig. 3) | DSB repair |
| Chromosome loss | Modest | This study (Fig. 5A) | Modest | This study (Fig. 5A) | DSB repair |
| Spontaneous HR | Yes | 3, 20, 44, 68 | Yes | 40; our unpublished results | Replication |
| MMS/HUc sensitivity | Yes | 7, 16, 40, 56; this study (Fig. 6A) | Yes | This study (Fig. 6A) | Replication |
| Lethality in srs2Δ | Yes | 15, 58, 64; this study (Fig. 6B) | Yes | This study (Fig. 6B) | Replication |
| Lethality in slx4Δ | Yes | 18 | Yes | 18 | Replication |
| Slow growth in top3Δ | Yes | 20 | Yes | 41; this study (data not shown) | Replication |
| Nuclear abnormalities | Yes | 37, 69; this study (Fig. 7D) | Yes | This study (Fig. 7D) | Chromosome segregation (replication?) |
a
Based on phenotypes observed in sgs1Δ.
b
Based on phenotypes observed in sgs1KA or sgs1KR.
c
HU, hydroxyurea.