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Survival after LPS/D-GalN challengea
| Strain (no. of animals) | No. moribund/no. healthy at:
|
|||
|---|---|---|---|---|
| 5 h | 6 h | 7 h | 8 h | |
| Wild type (8) | 0/8 | 3/8 | 6/8 | 8/8 |
| LTαΔ/Δ (8) | 0/8 | 2/8 | 4/8* | 8/8** |
| LTα−/− (7) | 0/7 | 0/7 | 0/7 | 3/7 |
| TNF KO (7) | 0/7 | 0/7 | 0/7 | 0/7 |
Mice were injected with 1 μg LPS and 20 mg D-GalN. A representative result of three independent experiments is shown. Data are shown as the ratios of severely moribund animals to healthy animals. * and **, LTαΔ/Δ versus LTα−/− (P ≤ 0.026).
