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(A) Depletion of prohibitin in MCF-7 cells by siRNA, as seen by Western blotting. (B) A ChIP assay showing the recruitment of HP1γ and Suv39H as well as K9 methylation on Cdc25A and TS promoters in MCF-7 cells transfected with control siRNA. (C and D) Depletion of prohibitin by siRNA did not affect the recruitment of Suv39H or K9 methylation upon senescence; the recruitment of HP1γ is completely inhibited. Si, siRNA.
