Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 Jun;26(12):4642–4651. doi: 10.1128/MCB.01655-05

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2006, American Society for Microbiology

PMC Copyright notice

FIG. 1. — NOTCH1 expression constructs. (A) Schematic representation of the human NOTCH1 receptor. N^EC, NOTCH1 extracellular subunit; N^TM, NOTCH1 transmembrane subunit; LNR, domain comprising the three LIN12/Notch repeats; HD, heterodimerization domain; HD-N, N-terminal region of the HD domain; HD-C, C-terminal region of the HD domain; TM, transmembrane segment; ICN, intracellular NOTCH1; RAM, RAM domain; ANK, ankyrin repeat domain; TAD, transactivation domain; PEST, PEST domain; S1, furin cleavage site. The 16 leukemia-derived HD domain mutations described in this article are shown. (B) NOTCH1 polypeptides used in these studies.