FIG. 6.

β-Cell proliferation and apoptosis. (a) RIPcre⁺ Pten^fl/fl mice tend to have a higher percentage of Ki67-positive cells than do their RIPcre⁺ Pten^+/+ littermates (n = 8 per genotype). (b) Effect of MLDS on blood glucose levels showing protection against MLDS-induced diabetes in RIPcre⁺ Pten^fl/fl mice (n = 2 to 5; age, 7 to 9 weeks). con, control; STZ, streptozotocin. (c) Representative islets of MLDS-treated RIPcre⁺ Pten^fl/fl and RIPcre⁺ Pten^+/+ mice stained for TUNEL, showing fewer TUNEL-positive nuclei in RIPcre⁺ Pten^fl/fl mice. +/+, RIPcre⁺ Pten^+/+ mice; −/−, RIPcre⁺ Pten^fl/fl mice.