TABLE 4.
ɛ-Globin gene expressions in (1.36kb γpr-β)(ΔGγAγ) YAC transgenic micea
| Line | Copy no. | Gene expressionb (mean ± SD) in:
|
||||
|---|---|---|---|---|---|---|
| Day 12 blood | Day 12 YS | Day 12 FL | Day 14 blood | Day 14 FL | ||
| A | 2 | 17.9 ± 1.7 | 19.3 ± 1.7 | 2.2 ± 0.6 | 1.1 ± 0.1 | 1.1 ± 1.0 |
| B | 1 | 8.3 ± 1.1 | 9.5 ± 2.0 | 0.9 ± 0.5 | 4.1 ± 0.1 | 1.2 ± 0.3 |
| C | 2 | 23.5 ± 2.6 | 23.2 ± 2.3 | 3.3 ± 0.8 | 2.8 ± 0.7 | 0.8 ± 0.1 |
| D | 1 | 32.2 ± 4.6 | 34.9 ± 4.3 | 4.3 ± 0.9 | 2.8 ± 1.0 | 0.8 ± 0.8 |
| E | 2 | 29.0 ± 2.8 | 37.2 ± 7.4 | 2.9 ± 0.6 | 2.8 ± 1.9 | 0.5 ± 0.3 |
| Avg | 22.2 ± 9.5 | 24.8 ± 11.4 | 2.7 ± 1.3 | 2.7 ± 1.1 | 0.9 ± 0.3 | |
| Amt of ɛ gene expression in wt YAC | 15.3 ± 1.7 | 16.5 ± 2.2 | 3.3 ± 1.4 | 2.6 ± 0.7 | 1.7 ± 0.3 | |
a
YS, yolk sac; FL, fetal liver; wt, wild type.
b
Percentage of α-like globin genes per copy.