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Met activates FAK through both the Met-Src-FAK pathway (our previous studies) and the Met-FAK pathway (this study). The activated FAK functions as a signaling platform to potentiate HGF-elicited signals, thereby contributing to HGF-stimulated cell motility and cell invasion. Note that the ability of FAK to promote HGF-stimulated invasion relies largely on its direct interaction with Met (see Discussion for details). P, phosphorylation.
