FIG. 2.

DNA sequence analysis reveals high degree of similarity between human and mouse FAT10 for expression regulation. The human and mouse FAT10 sequences that were compared encompassed the two exons, the intermediate intron, and a 2-kb upstream sequence that includes the 5′ untranslated region (5′UTR) and the promoter regions. TRANSFAC analysis (http://www.gene-regulation.com/pub/databases.html) was performed for the regulatory binding sites. NF-κB, IRF, and AP-1 are shown schematically for both strands.