A photograph of the Coomassie Blue-stained
SDS-PAGE protein gel of soluble proteins from E. coli after
cell disruption and ammonium sulfate fractionation. Lane 1,
Mr markers; lane 2, extract from cells
expressing wild-type GM-mI-PS-1a under control of the T7
promoter; lane 3, extract from wild-type GM-mI-PS-1a in
which residue K396 was changed to N396 by site directed mutation; lane
4, GM-mI-PS-1a from the LR33 mutant; lane 5, an extract from
control E. coli DE3 cells. The specific activity of
myo-inositol 1-phosphate synthase in lanes 2 through 4 is
listed below the lane.