Table 1.

Polarographic studies of the effects of KICA on mitochondrial function in intact C6 glioma cells

	Control (n = 3)	KICA (n = 4)
Oxygen consumption (mmol O2 · min−1 · mg protein−1)	19.9  ± 1.0	4.0  ± 2.5
Succinate oxidation rate without exogenous cyt c (mmol O2 · min−1 · mg protein−1)	20.4  ± 0.7	21.8  ± 1.3
Succinate oxidation rate with exogenous cyt c (mmol O2 · min−1 · mg protein−1)	20.4  ± 0.7	21.8  ± 1.3

Oxygen consumption in intact cells was assessed after a 4-h exposure to 50 mM KICA or medium alone (control). Succinate oxidation was measured (after the same treatment) in cells permeabilized with digitonin in the presence or absence of cytochrome c (cyt c). Results are expressed as mean ± SEM.