FIG. 5.

Nematodes treated with STI571 are resistant to S. flexneri-mediated C. elegans killing. (A to C) Young adult hermaphrodite nematodes were fed on lawns of either E. coli OP50 or S. flexneri 2457T at 25°C in the presence of PBS (A) or 0.5 μM (B) or 1 μM (C) STI571, and nematodes were scored daily for survival. The survival curve represents data from 3 independent experiments, each using 20 nematodes. (D) The relative mortality was calculated using the TD₅₀ values (representing data from three independent experiments) for the PBS and STI571-treated nematodes, in order to normalize the survival rates of the nematodes grown on S. flexneri 2457T compared to that of nematodes fed on E. coli OP50 (2).