FIG. 6.

STI571 is targeting ABL-1 during S. flexneri infection. (A and B) Vector (A) or abl-1 RNAi (B) young adult hermaphrodite nematodes were fed on lawns of either E. coli OP50 or S. flexneri 2457T at 25°C in the presence of PBS (filled symbols) or 1 μM STI571 (open symbols), and nematodes were scored daily for survival. The survival curve represents data from 4 independent experiments, each using 20 nematodes. (C) The relative mortality was calculated using the TD₅₀ values (representing data from four independent experiments) for the PBS and STI571-treated nematodes, in order to normalize the survival rates of the nematodes grown on S. flexneri 2457T compared to that of nematodes fed on E. coli OP50 (2).