TABLE 5.
In vitro activity of amphotericin B, fluconazole, and flucytosine against Norwegian candidemia isolates
| Species | Antifungal agent (no. of isolates) | MIC range (μg/ml) | MIC50 (μg/ml) | MIC90 (μg/ml) |
|---|---|---|---|---|
| C. albicans | Amphotericin B (934) | 0.06-2 | 0.5 | 1 |
| Fluconazole (934) | 0.25-4 | 0.5 | 1 | |
| Flucytosine (734) | 0.06-64 | 0.125 | 0.5 | |
| C. glabrata | Amphotericin B (180) | 0.06-2 | 0.5 | 1 |
| Fluconazole (180) | 1-64 | 16 | 64 | |
| Flucytosine (138) | 0.06-32 | 0.125 | 0.25 | |
| C. tropicalis | Amphotericin B (93) | 0.06-1 | 0.5 | 1 |
| Fluconazole (93) | 0.5-64 | 1 | 4 | |
| Flucytosine (81) | 0.06-64 | 0.125 | 0.5 | |
| C. parapsilosis | Amphotericin B (82) | 0.06-1 | 0.5 | 1 |
| Fluconazole (82) | 0.25-16 | 1 | 2 | |
| Flucytosine (69) | 0.125-1 | 0.125 | 0.25 | |
| C. krusei | Amphotericin B (22) | 0.25-2 | 1 | 2 |
| Fluconazole (22) | 32-64 | 64 | 64 | |
| Flucytosine (17) | 16-32 | 16 | 32 | |
| Othera | Amphotericin B (37) | 0.06-1 | 0.5 | 1 |
| Fluconazole (37) | 0.25-64 | 0.5 | 64 | |
| Flucytosine (26) | 0.06-64 | 0.25 | 16 | |
| All isolates | Amphotericin B (1,348) | 0.06-2 | 0.5 | 1 |
| Fluconazole (1,348) | 0.25-64 | 0.5 | 16 | |
| Flucytosine (1,065) | 0.06-64 | 0.125 | 0.5 |
a
Other species include C. blankii, C. dubliniensis, C. guilliermondii, C. kefyr, C. lusitaniae, C. norvegensis, C. sake, and C. sphaerica.