TABLE 1.
Values for the production rate ratio (p) for site-directed mutants of HIV-1 PR and RT
| PR or RT | Mutant/Thy allele | No. of replicates | Production rate ratio (p) relative to wild-type virus | SD | Pa |
|---|---|---|---|---|---|
| PR | D30N/Thy1.1 | 5 | −0.64 | 0.10 | <0.0001 |
| L90M/Thy1.1 | 6 | 0.09 | 0.17 | 0.3836 | |
| RT | K103N/Thy1.1 | 9 | 0.03 | 0.12 | NA |
| V106A/Thy1.1 | 5 | −0.12 | 0.08 | 0.0270 | |
| G190S/Thy1.1 | 14 | −0.28 | 0.12 | <0.0001 | |
| P236L/Thy1.1 | 8 | −0.23 | 0.07 | <0.0001 | |
| PR | D30N/Thy1.2 | 6 | −0.47 | 0.11 | <0.0001 |
| L90M/Thy1.2 | 6 | −0.04 | 0.11 | 0.3595 | |
| RT | K103N/Thy1.2 | 9 | −0.08 | 0.09 | NA |
| V106A/Thy1.2 | 8 | −0.22 | 0.03 | 0.0018 | |
| G190S/Thy1.2 | 11 | −0.34 | 0.09 | <0.0001 | |
| P236L/Thy1.2 | 6 | −0.29 | 0.06 | <0.0001 |
a
That is, the P value comparing the production rate ratio to K103N with the same Thy allele(s). A significant P value, corrected for nonorthogonal multiple comparisons based on Bonferroni t procedure (Bonferroni adjustment), is considered to be <0.01 (0.05/5). The correction is based on a total of five pairwise comparisons: each mutant versus K103N in the same Thy background.