Conserved Pfam domains identified in TTN6
(UBP14)-related proteins from different organisms. TTN6 contains all of
the protein domains expected for DUBs of the isopeptidase T class. Pfam
analysis (Bateman et al., 2000) revealed the presence of a zinc finger
UBP domain (ellipse), UCH-1 domain (diamond) with conserved “Cys”
box, two UBA domains (hexagons), and a C-terminal UCH-2 domain with
conserved “His” box in the expected locations. Organisms and
GenBank accession numbers: A, Arabidopsis, TTN6, AAG42755; B, rice,
BAB17073; C, human, XP_006971; D, Mus musculus, NP_038728;
E, S. cerevisiae, UBP14, NP_009614; F, D.
discoideum, P54201; G, fruit fly, AAF47720.