TABLE 1.
Characteristics of GAS isolates from eight villages in Nepal
| emm subtype (T pattern) | No. of isolates
|
mga locus patterna | Village(s) | ST | sof type (other sof type[s] linked with emm typeb) | Other locations with related strainsc | |
|---|---|---|---|---|---|---|---|
| Throat | Skin | ||||||
| 1.0 (1) | 0 | 9 | A-C | e, f | 28 | Negative | United States, Chile, Brazil, India, Poland, Czech Republic, United Kingdom |
| 4.0 (4) | 0 | 7 | E | d, f | 39 | 4 (2920) | United States, Germany, Czech Republic, United Kingdom |
| 4.2 (8/25) | 1 | 0 | E | a | 289 | 2920 (4) | Australia, Brazil |
| 11.0 (11) | 3 | 1 | E | b, e | 999 | 25 (11) | United States (DLV), United Kingdom (DLV) |
| 22.8 (2) | 2 | 0 | E | h | 360 | 174901 (22) | None known |
| 25.2 (14) | 2 | 1 | E | e | 350 | 4470 (25, 4958) | United States |
| 43.3 (3/13) | 0 | 1 | D | b | 343 | Negative | None known |
| 44.0 (11/12) | 3 | 3 | E | b, e, g, h | 351 | 3930 (44, 61) | Australia, Brazil |
| 49.4 (12) | 1 | 0 | E | h | 228 | 66 (49) | India |
| 53.0 (3/13/B) | 1 | 0 | D | a | 344 | Negative | Trinidad (DLV), United States (DLV) |
| 53.0 (13/1) | 0 | 2 | D | d | 363 | Negative | None known |
| 55.0 (NT) | 1 | 0 | A-C | f | 100 | Negative | Trinidad, United Kingdom |
| 56.0 (3/13) | 1 | 1 | D | g, h | 355 | Negative | Australia |
| 57.0 (3) | 2 | 1 | A-C | a, b | 348 | Negative | None known |
| 63.3 (6) | 0 | 1 | E | h | 297 | 76301 | Australia, United Kingdom |
| 63.4 (3/2/5/4) | 1 | 0 | E | E | 359 | 107 | Malaysia |
| 65.0 (3/13) | 1 | 1 | D | g | 129 | Negative | Egypt |
| 66.0 (4) | 2 | 0 | E | d, f | 249 | 137001 (66) | India, United Arab Emirates |
| 67.0 (3/13) | 2 | 0 | D | e, g | 267 | Negative | United Arab Emirates |
| 68.0 (1/13) | 0 | 1 | E | h | 361 | 68 (4438, 4470) | Egypt, United States |
| 70.0 (3/13) | 0 | 1 | D | a | 24 | Negative | Japan |
| 71.0 (14) | 3 | 3 | D | b, f, g, h | 130 | Negative | Egypt |
| 73.0 (3/13) | 4 | 0 | E | c | 331 | 73 | United Kingdom, United States |
| 74.0 (13) | 2 | 0 | D | e | 120 | Negative | Australia |
| 75.1 (NT) | 1 | 0 | E | e | 230 | 170901 (75, 4958) | United Arab Emirates |
| 75.1 (2/8/14) | 1 | 0 | E | g | 357 | 94 (94) | None known |
| 77.0 (2) | 3 | 1 | E | a, c, d, f | 347 | 131501 (77, 27L) | Poland (SLV) |
| 78.0 (3/5/27/44) | 1 | 1 | E | b, e | 181 | 170201 | Australia |
| 79.1 (12) | 5 | 0 | E | a, f | 362 | 130501 (79) | None known |
| 82.1 (3/13) | 4 | 1 | E | b, f, h | 320 | 74801 (82) | Egypt |
| 85.0 (3/13/B) | 0 | 2 | E | c, h | 109 | 76 | Australia, Trinidad, United States |
| 88.1 (NT) | 1 | 0 | E | c | 352 | 87 (88) | None known |
| 89.0 (13) | 1 | 2 | E | d | 356 | 136501 (89, 4835) | None known |
| 97.1 (NT) | 1 | 0 | D | b | 345 | Negative | None known |
| 100.1 (6/28) | 1 | 3 | D | a, f, h | 119 | Negative | Australia |
| 102.2 (11/12) | 3 | 1 | E | g, h | 349 | 102 | Australia, United States |
| 103.0 (13/B) | 0 | 1 | E | b | 201 | 103 | New Guinea, Malaysia, Brazil, United States |
| 104.0 (3/B) | 1 | 0 | E | c | 353 | 104 | Egypt |
| 105.0 (NT) | 1 | 0 | D | g | 151 | Negative | Malaysia |
| 106.0 (3/5/27/44) | 0 | 1 | E | b | 140 | 106 | Malaysia |
| 106.1 (3/5/27/44) | 1 | 0 | E | b | ND | 106 | Malaysia |
| 111.1 (NT) | 2 | 0 | D | f, g | 214, 346e | Negative | United Arab Emirates, Japan (DLV) |
| 116.1 (NT) | 1 | 0 | D | c | 227 | Negative | United Arab Emirates |
| 118.0 (12) | 2 | 0 | E | d, e | 354 | 118 | United Kingdom (DLV), United States (DLV) |
| 119.2 (NT) | 1 | 0 | D | f | 237 | Negative | United Arab Emirates |
| 122.0 (12) | 0 | 2 | D | c | 342 | Negative | None known |
| st1389.0 (13/B) | 1 | 1 | E | a, e | 358 | 1389 | United States |
| st1731.0 (12) | 2 | 0 | E | f, g | 303 | 1731 | None known |
| st2147.0 (8/25/I) | 0 | 2 | E | a | 169 | 2147 | Egypt |
| st6030.0 | 0 | 2 | D | a, c | 294 | Negative | United States |
| 1 | 0 | D | e | 224 | Negative | United Arab Emirates, Egypt (SLV) | |
| Total | 67 | 53 | |||||
a
See reference 4 for mga locus pattern information.
c
Strains with the same emm type combined with a related ST and/or the same sof type were considered related. STs are considered related if they share five to seven identical alleles; STs from the indicated locations are identical unless indicated in parentheses. SLV, single-locus variant; DLV, double-locus variant.
d
Entries in bold indicate there is the same emm-sof association as for the indicated Nepal isolates without accompanying MLST data.
e
STs 214 and 346 are SLVs associated with the emm111.1 isolates.