TABLE 4.
Diagnostic performance of the IgM-capture assays with recombinant chimeric antigens or the whole-cell Toxoplasma antigena
| Diagnostic testb | Pc | Sensitivity (%) | Specificity (%) | Agreement (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|
| ELFA Toxo-IgM | <0.0001 | 100 | 100 | 100 | 100 | 100 |
| ETI-TOXOK-M | <0.0001 | 98.0 | 100 | 98.9 | 100 | 97.6 |
| EC2 IgM Rec-ELISA | <0.0001 | 98.0 | 100 | 98.9 | 100 | 97.6 |
| EC3 IgM Rec-ELISA | <0.0001 | 84.0 | 100 | 91.1 | 100 | 83.3 |
a
PPV, positive predictive value; NPV, negative predictive value.
b
The ELFA Toxo-IgM assay was used as the “reference test” to evaluate the performances of the other assays (ETI-TOXO and Rec-ELISAs).
c
P values were determined by the chi-square test by comparison of the results for the Toxoplasma IgM-positive sera (group B; n = 50) and the IgM-negative sera (groups A and C; n = 40).