TABLE 3.

Mutations in the rpoB gene of 104 consecutive rifampin-resistant isolates identified in southern Vietnam

Mutated E. coli codon(s)	M. tuberculosis mutation(s)	Amino acid change(s)	No. (%) of isolates
146	G508T	V170F	1 (0.96)
511, 526	T1288C, C1333A	L430P, H445N	1 (0.96)
511, 512	T1288C, A1290G	L430P, S431G	1 (0.96)
511, 516	T1288C, A1304G	L430P, D435G	1 (0.96)
513	C1293A	Q432K	2 (1.92)
513	A1294T	Q432L	1 (0.96)
513, 526	C1293A, C1333G	Q432L, H445D	1 (0.96)
514	Insa: 1299TTC1300	Ins: F, QFM→QFFM	1 (0.96)
516	A1304T	D435V	9 (8.65)
516	A1304C	D435A	1 (0.96)
516, 526	A1304C, C1333A	D435A, H445N	1 (0.96)
516, 526	A1304T, C1335G	D435V, H445Q	1 (0.96)
516, 533	A1304G, T1355C	D435G, L452P	2 (1.92)
521, 516	Ins: 1320TCGGGGTTG1333, A1304G	Ins: SGL, PLSGL→PLSGLSGL, D435G	1 (0.96)
526	C1333T	H445Y	14 (13.46)
526	C1333G	H445D	6 (5.76)
526	A1334G	H445R	5 (4.81)
526	C1333A, A1334G	H445S	1 (0.96)
526	C1335G	H445Q	1 (0.96)
526	A1334T	H445L	1 (0.96)
526	C1333T, A1334T	H445F	1 (0.96)
531	C1349T	S450L	42 (40.38)
531, 561	C1349T, A1387G	S450L, I480V	3 (2.88)
533	T1355C	L452P	2 (1.92)
No mutations			4 (3.85)

^aIns, insertion.