TABLE 1.

Virological and clinical features of patients infected by natural HBV mutants

Patient no.	HBV genotype	HBsAg mutation(s)	Presence of HBeAg/HBeAb	Viral load (log copies/ml)	Clinical status
1	D	S204R/K, L205V, C/Y206S D/S207N, I208T	−/+	5.5	Chronic hepatitis
2	D	P120T, S132F, Y134N E/D144G	−/+	5.2	Chronic hepatitis
3	D	S143L	−/+	3.1	Chronic hepatitis
4	A	D144E, G145R	+/−	6.0	Acute hepatitis, HIV-coinfected patient, lamivudine (3TC)-resistant HBV delta virus superinfection
5	B	T126A, M133I	−/+	3.3	Chronic hepatitis
6	D	S143L	−/+	4.4	Moroccan blood donor
7	D	I110M, T116N, S117T, T118S, T140S, S143L	−/+	1.7	Moroccan blood donor
8	D	P127T, G145R	−/+	5.3	Liver transplant patient, HBV recurrence after 2 yr of HBIG escape
9	D	F134V, D144G	−/+	6.3	Liver transplant patient, HBV recurrence after 2 yr of HBIG escape
10	D	T126, I Y134H, P142L, G145R	−/+	6.0	Liver transplant patient, HBV recurrence after 1.5 yr of HBIG escape but HBIG maintenance
11	A	P120S, D144E, G145R, T189I	−/+	5.0	Liver transplant patient, HBIG escape
12	E	G145A	−/+	6.0	Liver transplant patient, HBIG escape
13	G	P108H, S113T	−/+	4.4	Chronic hepatitis 6 mo after 3TC initiation
14	D	M133I, Y134H, S143M	+/−	6.6	HIV-coinfected patient, 3TC-resistant HBV
15	D	L109I, G112K/R, S113A, P120T, F/Y134S	−/+	7.5	HIV-coinfected patient, HBV reactivation from anti-HBc alone (previous status)
16	F	S143L	−/+	6.2	Renal transplant patient, HBV reactivation
17	C	I/L110R, S117, I G119R, T123N, C124R, P203R	−/+	5.4	Liver transplant patient, HBV recurrence after 2 yr of HBIG escape, 18 mo after adefovir initiation