TABLE 1.
Appearance of mutations in four genomic segments as detected by direct sequencing
| Length of therapy (mo) | HBV DNAa (log copies/ml) | Therapyb | Base at indicated nt in the following segment:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Polymerasec
|
Core promoter
|
Precore
|
Core
|
||||||||
| 667 (180) | 739 (204) | 1757 | 1775 | 1837 | 1846 | 1909 | 1913 | 1915 | |||
| −4 | 6.9 | C | A | A | G | A | A | T | C | G | |
| 0 | 4.0 | Lam | C | A | A | G | A | A | T | C | G |
| 10 | 4.2 | Lam | C | A | A | G | A | A | T | C | G |
| 21 | 5.5 | Lam | A | G | A | A | G | T | C | A | G |
| 27 | 6.5 | Lam | A | G | A | A | G | T | C | A | G |
| 31 | 6.4 | Lam | A | G | G | A | G/A | T | C/T | A | G/C |
| 36 | 6.5 | Lam | A | G | G | A | G/A | T | C/T | A | C |
| 39 | 3.4 | Lam + Adv | C | A | A | A | G | T | C/T | A | G |
a
Measured by S-region TaqMan PCR.
b
Lam, lamivudine; Adv, adefovir.
c
For polymerase segment nt positions, the numbers in parentheses indicate the corresponding amino acid positions.