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Serum bactericidal titers of individual subjects after MPSV challenge in relation to prechallenge titers. (A) MCV/naïve group. (B) PCV/naïve group. (C) MCV/MPSV subset that received MPSV <3 years prior to enrollment. (D) MCV/MPSV subset that received MPSV ≥3 years prior to enrollment. “n” refers to the number of subjects who had bactericidal titers below the limit of detection in sera obtained before and after the MPSV challenge.
