TABLE 2.
Serum IgG group C anticapsular responsesa
| Group | No. of subjects | Geometric mean IgG [μg/ml (95% CI)]
|
||
|---|---|---|---|---|
| Preconjugate | Pre-MPSV boost | Post-MPSV boost | ||
| MCV/naïve | 35 | 0.4 A (0.2-0.6) | 2.2 B (1.0-4.6) | 6.1 C (3.6-10.2) |
| PCV/naïve | 34 | 0.3 (0.2-0.3) | 0.2 D (0.2-0.3) | 0.5 E (0.3-0.9) |
| MCV/MPSV <3 yr prior | 14 | 4.9 F (1.8-13.4) | 7.7 G (2.8-21.0) | 7.5 H (2.9-19.5) |
| MCV/MPSV ≥3 yr prior | 12 | 0.9 I (0.3-2.3) | 2.3 J (0.6-8.4) | 4.1 K (1.5-11.7) |
a
For comparison between A and B, P < 0.0001; for comparison between F and G, P = 0.2; for comparison between I and J, P = 0.006; for comparison between B and C, P < 0.0001; for comparison between D and E, P < 0.002; for comparison between G and H, P = 0.9; for comparison between J and K, P < 0.02 (paired t test). For comparison between C and E, P < 0.0001; for comparison between E and H, P < 0.0001; for comparison between E and K, P = 0.0002 (unpaired t test).