TABLE 3.
Serum bactericidal antibody responsesa
| Group | No. of subjects | Bactericidal antibody titer [1/GMT (95% CI)]
|
||
|---|---|---|---|---|
| Preconjugate | Pre-MPSV boost | Post-MPSV boost | ||
| MCV/naïve | 35 | 7.2 A (4.2-12.3) | 44.7 B (23.1-86.7) | 140.2 C (80.8-243.2) |
| PCV/naïve | 34 | 8.2 (5.8-11.6) | 7.4 D (5.1-10.7) | 20.4 E (12.8-32.4) |
| MCV/MPSV <3 yrs prior | 14 | 37.9 F (16.8-85.3) | 87.7 G (30.5-252.2) | 83.0 H (31.3-220.4) |
| MCV/MPSV ≥3 yrs prior | 12 | 22.3 I (8.8-56.7) | 67.1 J (23.5-191.9) | 111.7 K (54.2-230.3) |
a
For comparison between A and B, P < 0.0001; for comparison between F and G, P = 0.07; for comparison between I and J, P = 0.02; for comparison between B and C, P < 0.0001; for comparison between D and E, P < 0.0001; for comparison between G and H, P = 0.7; for comparison between J and K, P < 0.05 (paired t test). For comparison between C and E, P < 0.0001; for comparison between E and H, P < 0.004; for comparison between E and K, P = 0.0003 (unpaired t test). GMT, geometric mean titer.