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Killing of P. aeruginosa in colony biofilms (squares) upon prolonged exposure to tobramycin (A) or ciprofloxacin (B). Filled symbols indicate antibiotic treatment and open symbols indicate the untreated controls. Killing of planktonic bacteria (filled circles) is shown for reference. Error bars indicate the standard errors of the means. The initial cell densities were 10.4 ± 0.2 log10 CFU per membrane for biofilms and 10.0 ± 0.1 log10 CFU ml−1 for planktonic cells.
