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Penetration of tobramycin (squares) and ciprofloxacin (circles) through colony biofilms of P. aeruginosa. Filled symbols indicate an experiment with colony biofilm present and open symbols indicate the sterile controls. Relative penetration is the ratio of the antibiotic concentration measured in the disk on the far side of the membrane assembly to the concentration of antibiotic in equilibrium with the agar. Error bars indicate the standard errors of the means.
