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. 2006 Jun;72(6):4172–4183. doi: 10.1128/AEM.00734-06

FIG. 1.

FIG. 1.

(A) Structure of steffimycin. (B) Genetic organization of the steffimycin biosynthesis gene cluster. White arrows, genes not involved in steffimycin biosynthesis; gray arrows, genes involved in steffimycin biosynthesis. The gray box represents the 2.9-kb HindIII-BamHI fragment used as a probe for cosmid library screening. KSEH, STFa, Stf2B3, and Stf3E5 represent DNA regions present in plasmids pEM4KSEH and pEM4STFa and in cosmids Stf2B3 and Stf3E5, respectively. (C) HPLC analysis of S. albus strains STFaC (containing pEM4STFa and pEM4) and STFaRHAM (containing pEM4STFa and pRHAM). Peaks 3, 4, 5, 6, and STF correspond to compounds in Fig. 4. AU, arbitrary units; B, BamHI; H, HindIII; Sn, SnaBI; Ev, EcoRV; STF, steffimycin.