TABLE 5.
Recovery at 6, 12, and 24 h of CFT073 degP and CFT073 skp mutants compared to wild type after mixed infection of the urinary tracta
| CFT073 gene deletion | Time (h) | Kidney
|
Bladder
|
||||
|---|---|---|---|---|---|---|---|
| Ratio | n | P | Ratio | n | P | ||
| degP | 6 | 1.10 | 7 | 0.90 | 0.34 | 10 | 0.25 |
| degP | 12 | 0.00 | 8 | NCb | 0.00 | 8 | 0.0003 |
| degP | 24 | 0.00 | 11 | <0.0001 | 0.00 | 10 | <0.0001 |
| skp | 6 | 0.10 | 6 | 0.03 | 0.10 | 6 | 0.03 |
| skp | 12 | 0.05 | 5 | 0.10 | 0.07 | 5 | 0.15 |
| skp | 24 | 0.09 | 6 | 0.09 | 0.11 | 8 | 0.01 |
a
CFT073 degP, WAM3155; CFT073 skp, WAM3170; wild type is WAM2267. Data shown are the ratio of mutant versus wild-type CFU (median); n, number of mice with infection; P, comparison by Mann-Whitney U test.
b
NC, not calculable (no recovered mutant).