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. 2006 Jul;74(7):3890–3896. doi: 10.1128/IAI.01949-05

FIG. 1.

FIG. 1.

Anti-inflammatory effect of doxycycline in animals with sterile meningitis. (A) Intracisternal injection of hiR6 resulted in release of large amounts of TNF-α into the CSF after 3 h (gray circles). Pretreatment with doxycycline reduced the amount of TNF-α released by 90% (open circles) (the asterisk indicates that the P value is <0.03 for a comparison with saline-treated animals at 3 h after infection [n = 3 for each group]). (B) Influx of PMNs into the CSF after injection of hiR6. Pretreatment with doxycycline significantly reduced the number of PMNs in CSF by 56% (the asterisk indicates that the P value is <0.05 for a comparison with saline-treated animals at 12 h after infection [n = 4 for each group]). WBC, white blood cells.