FIG. 1.

Concentrations of pyrimethamine (Pyr) and sulfadoxine (Sulf) in plasma of 106 patients treated with sulfadoxine-pyrimethamine and of MdAQ in plasma of 112 patients treated with AQ in Gabon, 2000. All measurements were done 3 days after initiation of treatment. Concentrations of pyrimethamine and MdAQ are indicated in nanograms/milliliter, and those of sulfadoxine are in micrograms/milliliter. For each treatment, each group of children is divided according to treatment efficacy: adequate clinical and parasitological response (▪) and therapeutic failure (□).