TABLE 2.

Revised WHO classification of treatment failures in areas of intense malaria transmission

Criterion
Early treatment failure
Development of danger signs or severe malaria on day 1, day 2 or day 3, in the presence of parasitemia
Parasitemia on day 3 with axillary temperature of ≥37.5°C
Parasitemia on day 2 higher than day 0 count
Parasitemia on day 3 ≥25% of count on day 0
Late treatment failure
LCF
Development of danger signs or severe malaria after day 3 in the presence of parasitemia
Presence of parasitemia and axillary temperature >37.5°C on any day from day 4 to day 28, without previously meeting any of the criteria of early treatment failure
LPF
Presence of parasitemia on any day from day 14 to day 28, and axillary temperature <37.5°C, without previously meeting any of the criteria of early treatment failure or late clinical failure
ACPR
Absence of parasitemia on day 28 irrespective of axillary temperature without previously meeting any of the criteria of early treatment failure or late clinical or parasitological failure