TABLE 4.
In vivo efficacy of AQ and SP treatments of nonsevere P. falciparum malaria attacks in children from southeast Gabon in 2000, according to the 2001 WHO classification applied to a 28-day follow-up studya
| Parameter | Value for group
|
P value | |
|---|---|---|---|
| AQ (n = 118) | SP (n = 114) | ||
| In vivo treatment response [no. (%) of children]b | |||
| ACPR | 77 (65.3) | 98 (86.0) | 0.0002 |
| ETF | 1 (0.8) | 2 (1.8) | |
| LTFc | |||
| LCF | 16 (13.6) | 3 (2.6) | |
| LPF | 24 (20.3) | 11 (9.6) | |
| Parasitological clearance by day 3 [no. (%) of children] | 97 (82.2) | 73 (64.0) | 0.003 |
| Mean axillary temperature (± SE) on day 3 | 36.4 (±0.03) | 36.6 (±0.05) | 0.002 |
a
Treatment response is divided into adequate clinical and parasitological response (ACPR), and early (ETF) or late (LTF) treatment failures. According to the presence or not of clinical symptoms, LTF is divided into LCF or LPF. See Materials and Methods for details.
b
One child treated with AQ and 3 treated with SP were monitored only until day 7.
c
LTF, late treatment failure.