TABLE 5.
Results of logistic regressions of ACPR on plasma concentrations of monodesethylamodiaquine (patients treated with AQ), sulfadoxine or pyrimethamine (patients treated with SP), and other covariatesa
| Variable | Odds ratio | 95% confidence interval | P value |
|---|---|---|---|
| Amodiaquine (> or ≤135 ng/ml) | 4.5 | 1.7-11.5 | 0.004 |
| Age | —b | — | 0.05 |
| Sulfadoxine (> or ≤100 μg/ml) | 9.8 | 1.9-50.3 | 0.009 |
| Glycemia | — | — | 0.06 |
| Pyrimethamine (> or ≤175 ng/ml) | 11.8 | 2.3-59.9 | 0.005 |
| Glycemia | — | — | 0.09 |
a
Drug thresholds were determined in order to maximize corresponding odds ratios (see the text for details). South-East Gabon, 2000.
b
—, odds ratios were not computed (quantitative variable).