TABLE 6.
Discrimination of therapeutic failures after AQ or SP administration, due to recrudescent parasites (presence of bands shared by the two patterns) from reinfections (appearance of new bands in the second pattern) using genotyping comparison of MSP-1 and MSP-2 molecular patterns of P. falciparum parasites in blood before treatment and at reappearance of parasites in blooda
| Drug | In vivo result | No. (%) of cases with:
|
||
|---|---|---|---|---|
| Recrudescence | Recrudescence + reinfection | Reinfection | ||
| AQ | LPF | 8 | 12 | 2 |
| LCF | 8 | 4 | 1 | |
| Total | 16 (46) | 16 (46) | 3 (8) | |
| SP | LPF | 4 | 7 | 0 |
| LCF | 0 | 1 | 0 | |
| Total | 4 (33) | 8 (67) | 0 | |
a
See Materials and Methods for details; southeast Gabon, 2000.