FIG. 1.

Lipopolysaccharide, peptidoglycan, and interleukin-1 activate MaxiK in the cytoplasmic membranes of human macrophages. Shown are open probabilities (means ± standard deviations) of the MaxiK channel in excised outside-out membrane patches in a bathing solution of Hanks balanced salt solution after the application of either LPS at the indicated concentrations (A), 5 μg/ml PG (B), or 15 ng/ml IL-1 (C) as a function of the applied membrane potential. Current/voltage curves were fitted to sigmoid functions. The data shown are representative of three independent experiments.