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Histology (A) and pathology (B) of corneal disease at 2 days (48 h) postinoculation with P. aeruginosa strain PA103 or the retS or exsA mutant at ∼106 CFU/5 μl in the 6-h healing murine model of infection. PMN infiltration of the central cornea was observed in eyes infected with the retS and exsA mutants. However, PMN migration appeared restricted to the peripheral cornea in eyes infected with wild-type PA103 (×1,200 magnification [A]).
