Wild-type PA103 |
Functional ExsA-regulated TTSS; expresses two known effectors, ExoU and ExoT |
13 |
Mutant PA103retS::Tn5
|
Tn5 insertion in retS, loss of ExsA-regulated TTSS and other epithelium-associated virulence mechanisms, upregulation of other virulence mechanisms, e.g., biofilm formation and exopolysaccharide expression |
20, 27, 42
|
Mutant PA103exsA::Ω |
Ω insertion in exsA, loss of ExsA-regulated TTSS and unknown ExsA-dependent virulence mechanisms |
16 |
Mutant PA103exoU Tn5::Tcr
|
Tn5 insertion in exoU, loss of ExoU, expression of functional ExsA-regulated TTSS and effector ExoT |
12 |
Mutant PA103exoT::Tcr
|
Tn insertion in exoT, loss of ExoT, expression of functional ExsA-regulated TTSS and effector ExoU |
12 |
Mutant PA103exoU exoT::Tcr
|
Expression of functional ExsA-regulated TTSS, no expression of ExoU or ExoT |
38 |