FIG. 2.

Photomicrographs of lung sections from (A and C) untreated (Ctrl) or (B and D) anti-CD4 Ab-treated mice infected for 3 weeks. The lung sections were stained with (A and B) hematoxylin and eosin or (C and D) PAS and examined under a microscope (×200). Lungs from untreated mice had severe inflammation, and cryptococcal cells were seen mainly in the macrophages. In contrast, the anti-CD4 group had significantly less inflammation and a larger number of cryptococcal cells were seen in the extracellular matrix. PAS-stained sections show bright pink staining in the untreated group versus dull pink staining in the airway epithelial cells from the anti-CD4 Ab-treated group.