TABLE 3.
Selected genes determined by microarray to be positively regulated under phoP overexpression conditionsa
| KIM IDb | Probec | Annotationd | P value | Fold change |
|---|---|---|---|---|
| y1794 | YPO1634 | Response regulator protein (phoP) | 1.81E-05 | 25.9 |
| y1918 | YPO2421 | Probable glycosyl transferase (pmrF) | 6.22E-06 | 13.1 |
| y1917 | YPO2422 | Conserved hypothetical protein (pmrH) | 3.07E-05 | 13.0 |
| y1919 | YPO2420 | Probable formyl transferase (pmrI) | 3.44E-06 | 11.0 |
| y2124e | YPO2292 | Putative lipoprotein | 1.31E-05 | 10.4 |
| y1920 | YPO2419 | Conserved hypothetical protein (pmrJ) | 3.44E-06 | 9.6 |
| y1877 | YPO1715 | Probable N-acetylmuramoyl-l-alanine amidase | 6.22E-06 | 9.5 |
| y2147e | YPO2174 | Putative nucleotide sugar dehydrogenase (ugd) | 1.31E-05 | 9.0 |
| y2816e | YPO1363 | Putative virulence factor (somA) | 6.40E-05 | 8.5 |
| y1921e | YPO2418 | Mannosyltransferase family protein (pmrK) | 6.40E-05 | 7.7 |
| y1795 | YPO1635 | Putative lipoprotein | 1.31E-05 | 7.2 |
| YPO1659 | Hypothetical protein | 2.38E-04 | 6.9 | |
| y1922 | YPO2417 | Putative membrane protein (pmrL) | 6.22E-06 | 6.7 |
| y2608e | YPO1559 | Hypothetical protein | 3.06E-05 | 6.4 |
| y0838 | y0838 | Putative dehydrogenase | 9.93E-06 | 5.2 |
| y1923 | YPO2416 | Putative membrane protein (pmrM) | 1.05E-05 | 5.0 |
| y0838 | YPO3352 | Putative zinc-binding dehydrogenase | 4.04E-04 | 4.4 |
| y3284 | y3284 | Hypothetical protein | 4.94E-04 | 3.9 |
| y0839 | YPO3351 | Putative dehydrogenase | 8.24E-04 | 3.7 |
| y1741 | YPO2449 | Putative LuxR family regulatory protein | 5.77E-04 | 3.2 |
| y0447 | y0447 | Hypothetical protein | 8.22E-05 | 3.2 |
| y0840 | y0840 | Putative dihydroxyacetone kinase | 1.74E-02 | 3.1 |
| y0840 | YPO3350 | Putative dihydroxyacetone kinase | 5.33E-04 | 3.1 |
| y0245 | YPO3624 | Putative aliphatic sulfonate binding protein | 2.30E-03 | 2.9 |
| y3948e | YPO0164 | Putative membrane receptor protein | 1.55E-02 | 2.8 |
| y0243 | YPO3626 | Putative aliphatic sulfonate transport permease protein | 1.22E-03 | 2.7 |
| y0246 | YPO3623 | Putative NAD(P)H-dependent flavin mononucleotide reductase | 5.77E-04 | 2.7 |
| y0244 | YPO3625 | Alkanesulfonate monooxygenase | 6.16E-04 | 2.6 |
| y3966 | YPO0185 | Putative taurine dioxygenase | 7.35E-03 | 2.6 |
| y2866 | YPO1318 | Putative ABC transport ATP-binding subunit | 2.98E-02 | 2.5 |
| y3964 | YPO0183 | Putative taurine transport ATP-binding protein | 2.50E-04 | 2.4 |
| y3968 | YPO0187 | Putative glycosyl transferase | 1.86E-02 | 2.4 |
| y0447 | YPO3783 | Putative membrane protein | 2.68E-04 | 2.4 |
| y2076 | YPO2234 | Putative carbon starvation protein A | 1.70E-02 | 2.3 |
| YPO1366 | Cold shock-like protein | 8.36E-03 | 2.3 | |
| y0025 | YPO3717 | Putative membrane protein | 8.09E-03 | 2.3 |
| y1803 | YPO1642 | Sucrose operon repressor LacI family | 3.79E-03 | 2.3 |
| y1189 | YPO2615 | Putative amino acid-binding protein precursor | 8.36E-03 | 2.2 |
| y3965 | YPO0184 | Putative taurine transport system permease protein | 6.97E-03 | 2.2 |
| y2865 | YPO1319 | Putative ABC transport integral membrane subunit | 1.19E-02 | 2.2 |
a
The 40 genes with greatest positive changes are shown.
b
Locus tag for the KIM sequence, if applicable.
c
Locus tag for CO92 or KIM corresponding to the oligonucleotide.
d
Annotation for the CO92 sequence. Selected gene designations are indicated in parentheses.
e
Gene identified as PhoP regulated in the Tn5-lacZ screen.