TABLE 2.

Functional categories of host genes modulated by T. gondii over 72 h^a

Functional class	No. of genes modulated at the indicated period postinfection
	Induced genesb			Repressed genesc
	1-4 h	6-24 h	48-72 h	1-4 h	6-24 h	48-72 h
Transcription	50	36	10	0	4	6
Signal transduction	49	33	7	0	0	7
Nutrient metabolism	38	30	4	1	3	13
Immune response	35	30	12	1	1	5
Cell cycle	22	16	2	0	0	1
Apoptosis	19	17	5	1	1	6
Cell structure	13	7	2	0	0	5
Protein degradation	11	6	1	1	1	2
Protein synthesis	10	7	2	0	0	2
Protein trafficking	9	5	0	0	0	0
Cell growth and proliferation	5	3	0	0	0	0
Heat shock/stress response	2	1	0	0	0	0
Total	263	191	45	4	10	48

^aDistribution of 401 functionally classified genes with reliable gene expression data.

^bSignificantly up-regulated ≥2-fold (gene expression ratio, ≥2.0; P ≤ 0.05 by t test).

^cSignificantly down-regulated ≥2-fold (gene expression ratio, ≤0.5; P ≤ 0.05 by t test).