TABLE 5.
Comparison of host transcriptional responses to T. gondii in PK13 cells and HFFsa
| Accession no.b | Protein (gene) | Fold change in gene expression in:
|
Time (h) p.i. | |
|---|---|---|---|---|
| PK13 cells | HFFs | |||
| P42831 | Small inducible cytokine A2 (MCP-1) | 3.27 | 10.00 | 2 |
| AAH07091 | Interferon-inducible protein with tetratricopeptide repeats 1 (IFIT1) | 2.09 | 3.34 | 6 |
| AAH21136 | Interferon gamma-inducible protein 30 (IFI30) | 2.02 | 2.19 | 6 |
| AAZ32767 | C-X-C chemokine receptor type 4 (CXCR4) | 2.06 | 9.17 | 24 |
| AAS22336 | CASP8 and FADD-like apoptosis regulator (CFLAR) | 2.20 | 4.05 | 24 |
| Q08353 | NF-κB inhibitor alpha (NFKBIA) | 2.27 | 2.46 | 2 |
| CAC95165 | Fatty acid-binding protein 3 (FABP3) | NSC | NSC | 6 |
| AAH08466 | Dolichol-phosphate mannosyltransferase (DPM1) | NSCc | NSC | 24 |
| AAH16800 | Fructose-bisphosphate aldolase A (ALDOA) | NSC | NSC | 24 |
| S64635 | Pyruvate kinase, M1 isozyme (PKM1) | NSC | NSC | 24 |
| AAQ15274 | Pyruvate kinase, M2 isozyme (PKM2) | NSC | NSC | 24 |
| CAA82246 | Glucose-6-phosphate isomerase (GPI) | NSC | NSC | 24 |
| AAH21901 | Ras suppressor protein 1 (RSU1) | 2.77 | NSC | 2 |
| AAA58623 | Glutathione S-transferase (GSTM) | 3.42 | NSC | 2 |
| AAH12612 | Cathepsin L (CTSL) | 2.67 | NSC | 2 |
| AAH00491 | Proliferating cell nuclear antigen (PCNA) | 2.11 | NSC | 2 |
| AAT77773 | Phosphoglycerate kinase 1 (PGK1) | NSC | 4.00 | 24 |
| AAF71751 | Urokinase plasminogen activator surface receptor (PLAUR) | NSC | 4.25 | 24 |
| P00355 | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) | NSC | 3.70 | 24 |
| BAA22372 | Squalene epoxidase (SQLE) | NSC | 5.00 | 24 |
a
Porcine kidney epithelial (PK13) cells were infected with T. gondii for 72 h (this study). HFFs were infected with T. gondii for 24 h (3).
b
From the NCBI protein database.
c
NSC, no significant change in gene expression.