TABLE 3.
MICs and PAEs of six H. influenzae strains
| Drug | MIC range (μg/ml) | Mean PAE (range) (h)a |
|---|---|---|
| LBM415 | 0.5-4.0 | 1.2 (0.8-2.2) |
| Erythromycin | 2.0-8.0 | 3.1 (2.0-4.4) |
| Azithromycin | 0.5-2.0 | 7.1 (5.6-9.2) |
| Clarithromycin | 2.0-8.0 | 3.4 (2.4-4.6) |
| Amoxicillin-clavulanate | 0.25-1.0 | 0.3 (0.0-0.9) |
| Cefpodoxime | 0.06-0.25 | 0.2 (0.1-0.6) |
| Cefuroxime | 0.5-2.0 | 0.6 (0.1-1.4) |
| Cefdinir | 0.25-0.5 | 0.6 (0.2-1.8) |
| Ciprofloxacin | 0.004-0.015 | 2.2 (1.6-3.4) |
| Levofloxacin | 0.008-0.015 | 3.8 (2.8-5.0) |
| Gatifloxacin | 0.004-0.015 | 3.4 (1.9-6.2) |
| Moxifloxacin | 0.008-0.03 | 3.6 (2.4-5.4) |
a
PAE induced by 1 h of exposure at 10× the MIC.