TABLE 2.
Population pharmacokinetic parameters for the base model of mefloquine
| Parameterb | Mefloquinea administered with artesunate in three doses (8 mg/kg/day)
|
|
|---|---|---|
| Estimated value (SE) | 90% Prediction interval | |
| CL/F (liters kg−1day−1) | 0.755 (0.041) | 0.436-1.306 |
| V/F (liters kg−1) | 10.172 (0.777) | 4.395-23.541 |
| ke (day−1) | 0.074 | |
| Elimination t1/2 (days) | 9.4 | |
| AUC0→∞ (ng/ml · day) | 31,788 | |
| σCL (CV) (%) | 33 | |
| σV (CV) (%) | 51 | |
| σɛ (ng/ml) | 179 | |
a
Data represent results for 50 patients and 201 concentrations (AIC = 2,908).
b
CL/F, apparent clearance; V/F, apparent volume of distribution; ke, elimination rate constant; t1/2, elimination half-life; AUC0→∞, area under the whole-blood concentration-time curve; σ2CL, unexplained between-subject variance around the population average CL/F; σ2V, unexplained between-subject variance around the population average V/F; σ2ɛ, variance of the residual error.