. 2006 Jul;50(7):2281–2285. doi: 10.1128/AAC.00040-06

TABLE 3.

Population pharmacokinetic model with covariates for mefloquine^a

Parameter^b	Estimated value (SE)	90% Prediction interval
Group
CL/F (liters/kg/day)	0.722 (0.034)	0.463-1.126
Effect of weight on CL/F	−0.011 (0.003)
V/F (liters kg⁻¹)	10.966 (0.863)	4.987-24.113
Effect of temp on V/F	−1.739 (0.594)
k_e (day⁻¹)	0.066
Elimination t_1/2 (day)	10.5
AUC_0→_∞ (ng/ml · day)	33,241
σ²_CL (CV) (%)	27
σ²_V (CV) (%)	48
σ²_ɛ (ng/ml)	179
Each patient^c
AUC_0→_∞ (ng/ml · day)	31,395	20,523-49,239
C_max (ng/ml)	2,202	915-3,730
T_max (day)	2.4	2.3-2.6

Data represent results for 50 patients and 201 concentrations (AIC = 2,892).

All parameter estimates are for the average person (admission temperature, 37°C; weight, 45 kg). CL/F, apparent clearance; V/F, apparent volume of distribution; k_e, elimination rate constant; t_1/2, elimination half-life; AUC_0→_∞, area under the whole-blood concentration-time curve; σ²_CL, unexplained between-subject variance around the population average CL/F; σ²_V, unexplained between-subject variance around the population average V/F; σ²_ɛ, variance of the residual error.

Values in columns 2 and 3 were calculated using the actual dose given and the actual time of dosing and represent median and 90% range values, respectively.