FIG. 1.

Direct antimicrobial activity of LL-37 against B. anthracis UM23-Cl2 measured by a 96-well plate assay to determine the extent of growth inhibition in the presence of LL-37 and a variety of chemical protease inhibitors: no inhibitors (▪), the metalloprotease inhibitor 5 mM EDTA (⧫), the serine protease inhibitor 4 mM Pefabloc combined with metalloprotease inhibitor 5 mM EDTA (▴), and the serine protease inhibitor 4 mM Pefabloc (•). Each experiment was performed at least three times; the error bars represent the standard deviation calculated from the mean values.