TABLE 3.
In vitro susceptibilities of wild-type, rtA194T, rtL180M+rtM204V, and rtA194T+rtL180M+rtM204V HBV to tenofovir in a transient-cell-based antiviral assay
| HBV | EC50 (μM)a | n | Fold resistanceb |
|---|---|---|---|
| Wild type | 0.13 ± 0.043 | 5 | 1.0 |
| rtA194T | 0.19 ± 0.059 | 4 | 1.5 |
| rtL180M+rtM204V | 0.27 ± 0.16 | 5 | 2.1 |
| rtA194T+rtL180M+rtM204V | 0.31 ± 0.041 | 4 | 2.4 |
a
Mean ± standard deviation from the indicated number of experiments (n).
b
The fold resistance is the ratio of the mutant EC50 and the wild-type EC50. The reported value is the mean of three or more independent experiments.