TABLE 2.

Activities of alkoxyalkyl esters of CDV, cCDV, and HPMPA against VV and CPV in PHK monolayers

Compound	VV		CPV		Cytotoxicity (μg/ml)		SIe
	EC50 (μg/ml)a	Fold decreaseb	EC50 (μg/ml)a	Fold decreaseb	MCC (μg/ml)c	CC50 (μg/ml)d	VV	CPV
HDP-CDV	0.48 ± 0.52	20	0.32 ± 0.19	30	20	0.18 ± 0.18	0.4	0.6
ODE-CDV	0.081 ± 0.079	130	0.053 ± 0.037	180	20	0.012 ± 0.011	0.2	0.3
OLP-CDV	0.40 ± 0.44	30	0.33 ± 0.23	30	20	0.034 ± 0.027	0.1	0.1
ODBG-CDV	0.058 ± 0.070	230	0.072 ± 0.071	170	>5	0.012 ± 0.011	0.2	0.2
OLE-CDV	0.065 ± 0.037	170	0.035 ± 0.022	290	>20	0.014 ± 0.013	0.2	0.4
CDV	5.8 ± 4.2		5.3 ± 2.1		>50	7.2 ± 6.7	1.2	1.4
OLE-cCDV	0.31 ± 0.32	110	0.12 ± 0.17	160	>20	0.055 ± 0.080	0.2	0.5
cCDV	18.9 ± 12.9		9.9 ± 5.7		>50	41.7 ± 34.9	2.2	4.2
HDP-HPMPA	0.079 ± 0.059	30	0.022 ± 0.023	50	2	0.021 ± 0.025	0.3	1.0
ODE-HPMPA	0.005 ± 0.000	560	0.0015 ± 0.0008	750	2	0.0078 ± 0.0110	2	5.2
HPMPA	1.5 ± 0.9		0.61 ± 0.28		20	0.53 ± 0.05	0.4	0.9

^aConcentration required to inhibit 50% of virus-induced CPE. The EC₅₀ values of each compound represent the mean ± standard deviation of the EC₅₀ values of at least two independent experiments.

^bFold decrease in EC₅₀ relative to that of the parental compound based on molar values, given the following molecular weights: HDP-CDV, 583.68; ODE-CDV, 581.71; OLP-CDV, 609.71; ODBG-CDV, 717.85; OLE-CDV, 595.68; CDV, 315.12; OLE-cCDV, 559.65; cCDV, 297.2; HDP-HPMPA, 585.72; ODE-HPMPA, 599.38; HPMPA, 325.

^cMinimum cytotoxic concentration required to alter cell morphology.

^dConcentration required to reduce cell growth by 50%. The CC₅₀ values of each compound represent the mean ± standard deviation of the CC₅₀ values of at least two independent experiments.

^eSelectivity index (ratio of CC₅₀ to E₅₀).