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. 2006 Jul;50(7):2533–2536. doi: 10.1128/AAC.00187-06

FIG. 1.

FIG. 1.

Multiple-sequence alignment of fungal ErgA domains with amino acid substitutions that confer resistance to TRB. Amino acid substitutions within regions of the Erg1 (ErgA) protein which confer resistance to TRB in S. cerevisiae are shown above the sequences (9, 10). The F389L mutation in the ErgA protein that corresponds to the F391L and F402L substitutions observed in the TRB-resistant isolates of A. nidulans and S. cerevisiae (respectively) is indicated. The L393F mutation observed in the TRB-resistant Trichophyton rubrum clinical isolate is also indicated (13).